培米替尼的使用方法和副作用是什么？

Cholangiocarcinoma is a malignant tumor originating from the bile duct epithelium and is more common in older women. The disease often has an insidious onset, and most patients have no obvious discomfort in the early stages. Therefore, most patients are in the terminal stage when diagnosed, and the prognosis is poor. Although surgery is currently the preferred treatment for patients with indicated cholangiocarcinoma, its 5-year overall survival rate is only 10% to 44%. Most patients with cholangiocarcinoma have reduced appetite and food intake due to bile duct obstruction, which seriously affects the patient's nutritional status. It is an oral tablet that has obtained "breakthrough drug" and "orphan drug" qualifications as well as "priority review" status. It is approved for the treatment of adult patients with previously treated and unresectable locally advanced or metastatic cholangiocarcinoma. Pemetinib is the first FDA-approved targeted therapy for cholangiocarcinoma.

What are the uses and side effects of pemetinib?

: The recommended dose is 13.5 mg orally daily for 14 days, followed by 7 days off in a 21-day cycle. Continue treatment until disease progression or unacceptable toxicity. Swallow the tablets whole, with or without food.

: Dry eyes, dry mouth, decreased appetite, hyper/hypophosphatemia (electrolyte imbalance), alopecia, diarrhea, vomiting, joint pain, eye toxicity, nail toxicity, fatigue, indigestion (taste distortion), nausea, abdominal pain, constipation, stomatitis, back pain, dry skin, etc.

Finally, the editor of Medical Companion Travel would like to remind all patients who are currently using pemetinib that there have been a lot of rumors on the Internet and various platforms recently saying that increasing the dose of the drug can improve the therapeutic effect, or reducing the dose of the drug can reduce the occurrence of side effects. These are without any basis. Only by following the doctor's instructions can the effect of the drug itself be maximized.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.