英菲格拉替尼怎么吃,需要注意什么?

Infigratinib, an innovative, oral, ATP-competitive FGFR1-3 tyrosine kinase inhibitor, was approved by the US FDA in 2021 for the treatment of adult patients with cholangiocarcinoma with fibroblast growth factor receptor 2 (FGFR2) fusion or rearrangement. Infigratinib is a globally innovative targeted drug for cholangiocarcinoma. So, how to eat and what should you pay attention to?

How to take Infigratinib

Infigratinib needs to be taken orally, and it needs to be taken on an empty stomach. The recommended dose is 125 mg, taken orally once a day for 21 days, and then stop treatment for 7 days. The cycle is 28 days. Patients should take it at least 1 hour before fasting or 2 hours after eating. It should be noted that infigratinib needs to be taken at the same time every day. It can be continued until disease progression or unacceptable toxicity occurs, but the capsules cannot be crushed, chewed or dissolved.

All drug dosage adjustments of Infigratinib should be used under the guidance of professional doctors in regular hospitals who have experience in using targeted drugs. And before taking the drug, it must be determined whether the patient has FGFR2 gene fusion or rearrangement, otherwise the product is not allowed to be taken.

What should you pay attention to when taking Infigratinib?

During treatment with Infigratinib, please note that this product can cause retinal pigment epithelial detachment (RPED). A comprehensive eye examination should be performed before starting, 1 month, 3 months after treatment, and every 3 months thereafter. For hyperphosphatemia and soft tissue mineralization, stop, reduce the dose, or permanently discontinue the drug as recommended. Infigratinib can cause harm to the fetus, and inform patients to use effective contraceptive methods. Patients can read the drug package insert for more details.

Infigratinib blocks downstream signaling cascades by selectively binding and inhibiting FGFR activity, inducing tumor cell death by reducing cancer cell proliferation. The above is how to take Infigratinib and what you need to pay attention to. I hope it can help you!

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

Recommended related articles: