福巴替尼的用药禁忌和副作用？

The contraindications for the use of forbatinib are mainly for people who are allergic to the drug. The most common adverse reactions of forbatinib are nail toxicity, musculoskeletal pain, constipation, diarrhea, fatigue, dry mouth, alopecia, stomatitis, abdominal pain, dry skin, joint pain, dysgeusia, dry eyes, nausea, anorexia, urinary tract infection, palmoplantar paresthesia syndrome and vomiting.

Medication contraindications

1. It is contraindicated in patients who are allergic to any component of forbatinib or are allergic to similar compounds.

2. For pregnant women, lactating women and women of childbearing potential, it is recommended to avoid the use of forbatinib because the drug may cause harm to the fetus or newborn.

Forbatinib side effects

1. Gastrointestinal reactions: Common ones include nausea, vomiting, diarrhea, oral ulcers, etc. These side effects are usually controllable, and doctors can give appropriate drugs to reduce symptoms.

2. Nervous system toxicity: Forbatinib may cause nervous system toxicity, manifested by sensory abnormalities, such as numbness, tingling and peripheral neuropathy in the hands and feet.

3. Myelosuppression: Forbatinib may inhibit the hematopoietic function of the bone marrow, leading to a decrease in the number of white blood cells, red blood cells and platelets, which may increase the risk of infection, fatigue and bleeding.

4. Cardiovascular side effects: Some patients may experience cardiovascular side effects such as arrhythmia and cardiotoxicity.

5. Allergic reactions: Forbatinib may cause allergic reactions, including skin redness, urticaria, difficulty breathing, etc.

Treatment measures for the side effects of forbatinib

1. Gastrointestinal reaction: During nausea and vomiting, attention should be paid to adjusting the diet. Try to keep the diet as light as possible and avoid eating spicy and irritating foods. If you develop mouth sores, you can use a chlorhexidine-containing mouthwash or other mouth protectant to relieve symptoms.

2. Nervous system toxicity: If symptoms of abnormal sensation and peripheral neuropathy occur, the doctor should be informed immediately. The doctor may reduce the dose or suspend treatment to reduce neurotoxicity.

3. Myelosuppression: If forbatinib causes bone marrow suppression, doctors may monitor blood indicators and adjust the dose or extend the treatment interval. In severe cases, blood transfusions or growth factors may be needed to stimulate hematopoiesis.

4. Cardiovascular side effects: Monitor cardiac function regularly and adjust the dose of forbatinib as needed. If arrhythmia or other cardiovascular problems occur, the doctor needs to be informed in time for treatment.

5. Allergic reaction: If allergic symptoms occur, the use of forbatinib should be stopped immediately, and anti-allergic drugs or other treatment options should be selected.

forbatinib

The recommended dose is 20 mg, which is five 4 mg tablets taken once daily until disease progression or unacceptable toxicity occurs.

It is recommended to take forbatinib at approximately the same time each day, with or without food. Forbatinib should be swallowed whole and should not be crushed, chewed, split or dissolved to avoid affecting the therapeutic effect.

Summary

The side effects and severity of forbatinib vary depending on individual differences. During the use of forbatinib, it is recommended to maintain close communication with your doctor and report discomfort symptoms or side effects in a timely manner so that your doctor can conduct timely evaluation and treatment.

Recommended related articles: