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Futibatinib is a targeted drug for the treatment of FGFR2 gene fusion/rearrangement cholangiocarcinoma. It has shown significant anti-tumor activity in patients with intrahepatic cholangiocarcinoma with FGFR2 gene fusion or rearrangement and can prolong the duration of response. It is suitable for adult patients with previously treated unresectable locally advanced or metastatic intrahepatic cholangiocarcinoma. The cost of treatment is a focus of patients. This article will analyze the treatment cost and usage specifications of this drug in detail from three aspects: drug dosage, cost structure and medication for special groups.

How many boxes of fobatinib per treatment course

The standard medication regimen needs to be determined based on the specific conditions of the patient, and there are individual differences in the dosage of treatment.

Calculation of standard dose

The recommended dose is 20 mg once a day (5 tablets of 4 mg). Based on 35 tablets/box, approximately 1.5 boxes are needed per month, and 4-5 boxes are required for a standard 3-month treatment course.

Dose adjustment factors

When adverse reactions of grade 3 or above occur, the dose may need to be reduced to 16 mg/day or 12 mg/day. In patients with severe liver damage, the starting dose needs to be adjusted to 12 mg/day.

Long-term treatment needs

Patients with clinical benefit can continue to take the drug until disease progression. A 6-month treatment course requires about 8-9 boxes, and a 1-year treatment course requires 16-18 boxes.

Patients should have regular follow-up visits, and the doctor will adjust the medication regimen based on efficacy and tolerance.

How much does a course of forbatinib cost?

As a new targeted drug, the treatment cost of fobatinib requires patients to plan in advance.

Generic drug cost details

Laos Lucius generic drug 4mg*35 tablets sells for US$480. The cost of a 3-month course of treatment (4.5 boxes) is approximately US$2,160, and the cost of a 6-month course of treatment is approximately US$4,320.

Cost Optimization Suggestions

Choosing generic drugs can save some costs. It is also recommended that patients pay attention to pharmaceutical company assistance programs to learn whether they can reduce their out-of-pocket drug costs.

The actual cost will change due to factors such as exchange rate and dosage adjustment. You should confirm the latest price before purchasing the drug.

Forbatinib medication for special groups

Patients with special physiological conditions must pay special attention to medication safety when using forbatinib.

Contraindicated for pregnant women

It has embryo-fetal toxicity. Use by pregnant women may cause fetal malformation or death. Women of childbearing age must take reliable contraceptive measures during use.

Breastfeeding restrictions

Breastfeeding is prohibited during treatment and within 1 week after stopping the drug. The drug may be secreted through breast milk and cause potential harm to the baby.

Patients with liver damage

Patients with bilirubin >1.5×ULN should use with caution as the risk of adverse reactions may increase. In patients with moderate hepatic impairment, the starting dose should be reduced to 12 mg/day.

Medicine use in special groups must be closely monitored, and any dosage adjustments should be made under the guidance of a professional doctor.