艾伏尼布的副作用如何缓解

Avosidenib is a targeted therapy drug for relapsed or refractory acute myeloid leukemia (AML) with IDH1 mutations. It has shown significant clinical efficacy, but is also accompanied by a series of possible adverse reactions, ranging from common mild adverse reactions such as fatigue, nausea, and vomiting, to more serious adverse reactions such as differentiation syndrome and significant prolongation of the QT interval.

Side effects of ivonib

1. Common adverse reactions

Common adverse reactions in the early stage include fatigue, joint pain, diarrhea, edema, nausea and a series of more common symptoms.

With the gradual deepening of treatment, many patients can gradually adapt to these adverse reactions in the early stages of medication.

2. Serious adverse reactions

In addition to common adverse reactions, a small number of patients may also experience more serious side effects, such as differentiation syndrome, significantly prolonged QTc interval, Guillain-Barré syndrome, etc.

Although these reactions are uncommon, they are highly dangerous and need to be identified and dealt with promptly.

3. Risk of side effects in special groups

For the elderly, patients with liver and kidney dysfunction, and patients taking other drugs for a long time, the risk of side effects of ivonib may be higher.

The pictures are from public channels (such as the official website of the FDA, the official website of the original drug manufacturer, etc.) and are for reference only.

How to alleviate the side effects of ivosidenib

The adoption of a systematic and graded mitigation strategy for the various adverse reactions caused by ivosidenib is particularly critical. Early identification, active intervention and individualized adjustment are the core of mitigating side effects and ensuring continuity of treatment.

1. Daily management of common symptoms

(1) For common reactions such as fatigue, nausea, and diarrhea, it is recommended that patients adjust their diet, eat smaller meals more frequently, avoid high-fat foods, and properly replenish water and electrolytes.

(2) Mild topical drugs, such as hydrocortisone cream, can be used for mild rashes.

(3) Maintain adequate rest and moderate activities to help relieve fatigue.

2. Medical intervention for severe side effects

If differentiation syndrome occurs, corticosteroids such as dexamethasone must be used immediately, and hemodynamic indicators must be closely monitored.

When QTc prolongation occurs, an electrocardiogram should be performed promptly, and medication should be suspended or the dose adjusted if necessary.

Efficacy of ivosidenib

1. Clinical response and survival benefit

Research shows that some patients treated with ivosidenib can achieve complete remission or hematological improvement.

Especially in patients with leukemia who carry IDH1, clinical trials of ivonib have shown good anti-tumor activity and relatively good tolerability.

2. Long-term treatment effect

Avosidenib can not only prolong the survival time of patients, but also significantly improve the prognosis of patient survival.

Patients should regularly evaluate molecular responses during medication, which will help dynamically adjust treatment strategies and improve treatment efficiency.