How many boxes of larotrectinib can be stocked at one time? How much does it cost?

The indications of larotrectinib are lung cancer, thyroid cancer, invasive melanoma, gastrointestinal cancer series (covering cancers in the stomach and intestinal tract), colon cancer, soft tissue sarcoma, salivary gland tumors, etc. Its purchase quantity and price are the focus of patients. This article will detail the purchase restrictions of this drug, the price differences between different versions, and the medication precautions for special groups.

How many boxes of larotinib can be stored at a time

is a specially managed drug, and its purchase quantity is strictly limited. Patients need to understand the relevant regulations.

Hospital purchase restrictions

Domestic hospitals usually limit each prescription to no more than one month's supply. For the 100mg specification, adult patients can generally purchase up to 2 boxes (30 capsules/box) at a time.

Pharmacy purchase regulations

Designated specialty drug pharmacies implement the same purchase restriction policy as hospitals. Complete medical records and prescriptions are required when purchasing. The pharmacy will register patient information and limit the purchase quantity.

Application under special circumstances

Patients from other places or under special circumstances can apply to the hospital’s Pharmacy Committee to increase the purchase amount. Sufficient reasons and relevant certificates must be provided, and a maximum of 3 months’ consumption can be approved.

After understanding the purchase quantity limit, price is an important consideration for patients when choosing drugs. The prices of each version will be introduced in detail below.

How much does larotinib cost

The price of larotinib varies significantly depending on the manufacturer and region, and patients can choose according to their actual situation.

Price of the imitation version in Laos

The price of 100mg*30 tablets produced by Lucius in Laos is about US$206 per box. Calculated based on standard dosage, the monthly treatment cost for adult patients is approximately US$412.

Price of Bangladeshi imitation version

Products of the same specification produced by Bangladesh Everest and Yaopin International are priced at approximately US$549 per box. The production technology of these two versions is more mature and the price is relatively high.

Original drug price

After Bayer’s original drug Vitrakvi is reimbursed by medical insurance, the patient’s out-of-pocket cost will be reduced and needs to be calculated according to the specific reimbursement ratio.

In addition to purchasing matters, special groups of people need special attention when using medicines. The relevant precautions will be introduced below.

Larotrectinib medication for special groups

There are specific precautions for using larotrectinib among different groups of people, and the medication regimen needs to be adjusted individually.

Pediatric medication

It can be used by children over 2 years old. The dosage needs to be adjusted according to the body surface area. Oral solution dosage forms are recommended for precise dosing. Growth and development need to be closely monitored during treatment.

Geriatric Medication

Elderly patients over 65 years old do not need to adjust the starting dose. However, because metabolic function may decline, adverse reaction monitoring needs to be strengthened and the dosage appropriately reduced if necessary.

Hepatic and renal insufficiency

No dose adjustment is required for mild hepatic and renal insufficiency. For moderate to severe patients, it is recommended that the starting dose be reduced by 50% and gradually increased according to tolerance. Liver and kidney function indicators need to be monitored regularly.

Pregnancy and lactation

It is embryotoxic and is contraindicated during pregnancy. Patients of childbearing age need to take reliable contraceptive measures during treatment. Breastfeeding women should suspend breastfeeding.

Larotinib is a prescription drug and should be used under the guidance of a doctor. When purchasing, choose formal channels to ensure the quality of medicines. During the treatment period, genetic testing and efficacy evaluation are performed regularly, and the medication plan is adjusted in a timely manner.