How to treat side effects caused by sotorasib?

is a new targeted therapy drug targeting the KRAS G12C mutation. Although it has shown significant efficacy in treating specific types of cancer, like most anti-cancer drugs, it may also be associated with a series of side effects. During treatment, patients may experience gastrointestinal reactions and other discomforts, which can be treated under the guidance of a doctor.

Side effects treatment methods

1. Gastrointestinal reactions: including diarrhea, nausea, vomiting and indigestion. Mild to moderate symptoms are usually managed with dietary modification and oral rehydration. Doctors may recommend that patients eat low-fat, easily digestible meals in small portions and take electrolyte drinks to prevent dehydration. Severe cases of diarrhea may require the use of antidiarrheal medications, such as loperamide, and prompt medical attention to avoid electrolyte imbalance and dehydration.

2. Abnormal liver function: Some patients may experience elevated liver enzymes, manifesting as fatigue, loss of appetite, skin jaundice and other symptoms. It is recommended to regularly monitor liver function indicators. Once abnormalities are found, doctors may adjust the dose of sotoraxib or temporarily discontinue the drug, and consider using hepatoprotective drugs, such as glutathione, silymarin, etc., to protect liver function.

3. Rash and dry skin: Some patients will develop mild to moderate rash, accompanied by itching or dry skin. Daily skin care is important, use gentle, non-irritating cleansers and moisturizers, and avoid hot water baths and rubbing your skin. Your doctor may prescribe a topical corticosteroid ointment to reduce inflammation and itching. In severe rashes, consult a doctor, who may need to adjust your treatment plan or use oral anti-allergy medications.

4. Fatigue: persistent physical weakness or lack of energy. Improve sleep quality by reasonably arranging rest time and engaging in moderate physical activities, such as walking or yoga, while maintaining nutritional balance. If necessary, auxiliary psychological support or energy regulation drugs can be considered.

5. Musculoskeletal pain: Some patients report muscle or joint pain. Over-the-counter pain relievers, such as acetaminophen or nonsteroidal anti-inflammatory drugs, are available to relieve mild to moderate pain. Applying hot or cold compresses can also help relieve localized discomfort. Severe pain should be treated with medical attention promptly to assess whether the treatment plan needs to be adjusted.

Comprehensive management strategy

It is recommended that patients should return to their doctors regularly to report any new symptoms or changes in side effects so that the treatment plan can be adjusted in a timely manner. The side effects that occur during treatment with sotoraxib are controllable. By communicating with the medical team in a timely manner and taking appropriate preventive and intervention measures, most patients can effectively alleviate these discomforts and continue to benefit from the treatment.