一种具有神经保护作用的新型抗癫痫药物-苯巴那酯

Phenobarnate (trade name: Studies have shown that it has an inhibitory effect on sustained sodium ion currents and has broad-spectrum anticonvulsant activity. It can effectively inhibit epilepsy in focal epilepsy models. It can also inhibit nerve impulses and reduce nerve excitability by regulating gamma-aminobutyric acid (GABA) receptors, thereby exerting anti-epileptic effects.

The effects of phenobarnate on voltage-gated sodium channels (VGSCs) and persistent sodium currents were studied, as increases in persistent sodium currents enhance neuronal excitability. This study showed that phenobutate (100 umol/L) had little inhibitory effect on transient currents but inhibited persistent sodium currents in a concentration-dependent manner. In addition, compared with carbamazepine and lamotrigine, c-phenate has a stronger inhibitory effect on persistent sodium currents. Phenobarate (100 umol/L) also accelerates the inactivation of VGSC and delays its recovery, thus making the drug more effective. Phenobarnate-mediated hyperpolarizing membrane potential mediated by persistent sodium current inhibition is concentration-dependent and reduces the number of action potentials induced by depolarizing currents.

Phenobarate can be taken with or without food. Take it with water and do not chew it. Monotherapy and adjunctive therapy: Phenobarate is taken orally once daily. Do not exceed recommended doses due to the potential for serious adverse reactions. Common side effects include shortening of the QT interval on electrocardiogram, systemic symptoms, suicidal behavior tendencies, multi-organ hypersensitivity reactions, neurological adverse reactions, discontinuation of anti-epileptic drugs, eosinophilia, etc.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.