托伐普坦有哪几个版本?分别多少钱?

This article focuses on the analysis of tolvaptan's version classification, price differences, listing and medical insurance coverage in China. It combines drug instructions and market information to systematically sort out the core content that patients and medical practitioners need to pay attention to. By clarifying the characteristics of drug versions, price ranges and medical insurance policies, it provides a reference for rational drug use.

What are the versions of tolvaptan?

It is a vasopressin V2 receptor antagonist. Its versions are mainly distinguished based on dosage specifications and production sources. Different versions have specific indications and usage scenarios.

Dosage specification version

Tolvaptan tablets include two strengths: 15mg and 30mg. The 15mg specification is often used for initial treatment or for patients who need to carefully adjust the dose, while the 30mg specification is suitable for situations where the efficacy needs to be strengthened after the condition is stabilized. Both specifications must be used in strict compliance with medical instructions to avoid the risk of osmotic demyelination caused by improper dosage.

Production source version

Tolvaptan currently on the market in China is mainly produced by Zhejiang Otsuka Pharmaceutical Co., Ltd., and domestic generic drugs. The distinction between original drugs and domestic generic drugs is clearly marked in the instructions, and the domestic version has passed the consistency evaluation. The imported version has not yet been widely circulated in the domestic market, and domestic preparations are mainly used for clinical use.

Different versions of tolvaptan have differences in packaging formats (such as double aluminum packaging, 5, 7 or 10 tablets per plate), but the core ingredients are consistent with the quality standards.

How much do different versions of tolvaptan cost?

Drug prices are significantly affected by dosage, packaging and medical insurance policies. Domestic tolvaptan has a certain price range due to differences in production costs and market strategies.

Price range of domestic preparations

The retail price of domestic tolvaptan is about US$28-69 per box, and the price after reimbursement will be lower, depending on the dosage and packaging specifications. The price of a single box of 15mg is usually lower than 30mg. Some regional pharmacies or online platforms may launch limited-time offers, and prices may fluctuate slightly.

Actual cost after medical insurance reimbursement

Domestic tolvaptan has been included in the national medical insurance catalog. The reimbursement ratio is adjusted according to local policies. Reimbursement must meet specific indication conditions, such as confirmed hyponatremia or heart failure and fluid retention. The imported version is not covered by medical insurance and has limited circulation.

The marketing and medical insurance coverage of tolvaptan in China

The domestic marketing and medical insurance coverage of tolvaptan reflects the policy’s support for innovative drugs while taking into account patient accessibility.

Localization and launch process

Tolvaptan tablets were approved for production by Zhejiang Otsuka Pharmaceutical Co., Ltd. in 2011, and the trade name is "Sumac®". The company strictly follows the Good Manufacturing Practice (GMP) to ensure that drug quality meets national standards. After localization, tolvaptan quickly replaced imported products and became the first-line choice for clinical treatment of hyponatremia.

Conditions for medical insurance inclusion and reimbursement

Domestic tolvaptan has been included in the National Medical Insurance Category B Catalog since 2020, covering indications including hypervolemic hyponatremia and heart failure and fluid retention. Patients need to apply for reimbursement with a doctor's prescription and diagnosis certificate. Some cities include liver cirrhosis-related hyponatremia in the management of special diseases, further reducing the out-of-pocket rate.

When using tolvaptan, you need to pay attention to the risk of hepatotoxicity. Patients must pay attention to monitoring liver function during the medication, and promptly notify the doctor if any abnormalities occur.