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The manufacturer is Pfizer Ireland Pharmaceuticals. The main ingredient of rapamin is sirolimus, also known as sirolimus tablets. It is suitable for patients who have received kidney transplants. It is recommended to be used in combination with cyclosporine and corticosteroids to prevent organ rejection.

Rapamin (sirolimus) inhibits the activation and proliferation of T lymphocytes stimulated by antigens and cytokines (interleukins IL-2, IL-4 and IL-15). It also inhibits the production of antibodies. In cells, rapamycin (sirolimus) binds to the immunophilin, FK-binding protein-12 (FKBP-12), to generate the FKBP-12 immunosuppressive complex. This complex binds to the mammalian rapamycin (sirolimus) BA molecule (mTOR, a key regulatory kinase) and inhibits its activity, thereby inhibiting the progression from the G1 phase to the S phase in the cell cycle.

Concomitant use of rapamycin with cyclosporine and corticosteroids is recommended. Take orally, once daily. It should be started as soon as possible after transplantation. For new transplant recipients, the loading dose should be taken, which is 3 times the maintenance dose. The recommended loading dose for kidney transplant patients is 6 mg and the maintenance dose is 2 mg/day. Although the loading dose of 15 mg and the maintenance dose of 5 mg/day used in clinical trials are satisfactory, the therapeutic benefit of doses above 2 mg is unclear for kidney transplant patients.

Sirolimus is rapidly absorbed from oral solution, with a mean time to peak of approximately 1 hour after a single oral dose; in renal transplant recipients, the mean time to peak after multiple oral doses is approximately 2 hours. High-fat meals can increase the absorption of sirolimus, so it is recommended that oral sirolimus should be taken regularly with or without food.

If patients want to purchase, please consult Medical Companion Travel, and we will provide you with a quick and convenient way to purchase medicines.