孕妇能不能服用雷帕鸣

(sirolimus) has a different immunosuppressive mechanism compared with calcineurin inhibitor drugs. Sirolimus can block the calcium-dependent and calcium-independent signaling pathways of T lymphocytes and B lymphocytes, inhibiting the body's immune function. It exerts anti-rejection effect without obvious liver, kidney and nervous system toxicity, and may play an important role in the prevention and treatment of chronic transplant nephropathy. Since it was approved for marketing in the United States in 1999, the drug has been further promoted and used in kidney transplant patients, and the usage of the drug has become a matter of great concern to patients.

So, can pregnant women take rapamycin (sirolimus tablets) for treatment?

Because there have been no adequate and well-controlled clinical trials in pregnant women, rapamin is not recommended for pregnant women. Female patients are advised to take effective contraceptive measures before starting treatment with this drug, during treatment and within 12 weeks after stopping treatment. During pregnancy, rapamin should only be used by pregnant women unless the potential benefits outweigh the potential risks to the embryo/fetus.

Based on the results of previous clinical trials, the most common adverse reactions (occurring in >10% of patients) in kidney transplant patients include diarrhea, pain, constipation, nausea, headache, abdominal pain, anemia, fever, hypertension, blood Decreased platelets, urinary tract infection, hypercholesterolemia, hyperglycemia, hypokalemia, hypophosphatemia, hypertriglyceridemia, lymphocele, peripheral edema, joint pain, acne, elevated serum creatinine levels, and elevated serum lactate dehydrogenase (LDH) levels.

When the symptoms of adverse reactions experienced by patients are mild, there is generally no need to adjust the dosage. Once the symptoms worsen, patients must receive timely and effective treatment, so as to effectively avoid the harm caused by improper medication.

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