西罗莫司片的注意事项

What are the precautions for (Leipaming)? Let’s take a look. Sirolimus tablets (Repamin) were extracted by scientists in 1975 from Streptomyces hygroscopicus isolated from the soil of Easter Island in Chile. Rapamycin is a new type of macrolide anti-rejection drug. It is the latest powerful immunosuppressant in the world. It is clinically used for anti-rejection of organ transplantation and the treatment of autoimmune diseases. Its immunosuppressive activity is dozens of times stronger than that of cyclosporine, which is currently widely used in clinical practice. It has low toxicity and small dosage. It also has a synergistic immunosuppressive effect with cyclosporine and is used clinically in combination with cyclosporine. Compared with cyclosporine and FK506, rapamycin is the least nephrotoxic immunosuppressant and has no neurotoxicity.

Precautions for Sirolimus Tablets (Repamin):

Interstitial lung disease occurs in patients receiving immunosuppressive therapy (including sirolimus tablets) without clear infectious agents, and some may be fatal. Such diseases include noninfectious pneumonia, bronchiolitis obliterans with organizing pneumonia (BOOP) (less frequently), and pulmonary fibrosis. In some cases, discontinuing sirolimus tablets (rapamin) or reducing the dose can eliminate this interstitial lung disease. As trough sirolimus plasma concentrations increase, the risk of developing this disease increases. Latent Viral Infection Nephropathy and progressive multifocal leukoencephalopathy (PML) associated with BK virus have been observed in patients receiving immunosuppressives, including rapamycin. This infection can be associated with serious or fatal consequences, including kidney transplant failure. Hepatotoxicity: Hepatotoxicity has been reported, including fatal hepatic necrosis due to elevated trough sirolimus concentrations (i.e., above therapeutic levels). Poor healing has been reported after transplant surgery, including fascial dehiscence, incisional hernia, and rupture of anastomotic sites (such as wounds, blood vessels, airways, ureters, biliary tracts, etc.). Other clinical experience has reported the occurrence of azoospermia in patients receiving Rapamin®, which improved in most patients after discontinuation of Sirolimus Tablets (rapamin). Clostridium difficile enterocolitis has been reported in patients receiving sirolimus.

The above are the precautions for (Rapa Ming) introduced to you by our medical companion tour. Patients must read the instructions carefully and use the medicine rationally.

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