西罗莫司片有什么作用？

(Rapamin) is a lipophilic triene nitrogen-containing macrolide antibiotic compound produced by Streptomyces hygroscopieus isolated from soil samples of Easier Island in the Pacific by Vezina et al. of Ayerst Laboratory in Canada in 1975. Sirolimus tablets (rapamin) are taken orally once a day. Concomitant use with cyclosporine and corticosteroids is recommended. Start taking your medications as soon as possible after your transplant. In new transplant recipients, the initial loading should be three times the maintenance dose. The recommended loading dose for kidney transplant recipients is 6 mg and the maintenance dose is 2 mg/day.

Initially used as a low-toxicity antifungal agent and immunosuppressant, RAPA began to be tested as a new drug for organ transplant rejection in 1989. From animal experiments and depending on the impact of clinical application, it is an effective and good, low-toxicity new immunosuppressant without nephrotoxicity. Compared with cyclosporine, sirolimus tablets (rapamin) have a smaller oral dose (only 2 to 3 mg per serving), a stronger anti-rejection effect, and fewer side effects.

Therefore, since sirolimus tablets (rapamin) were listed on the market, they have rapidly developed into a commonly used oral immune system suppressant for patients undergoing transplantation of different organs around the world (especially for kidney transplantation). Sirolimus (rapamycin) is a serine/threonine kinase regulated by phosphoinositide-3-kinase and an mTOR (mammalian target of rapamycin) inhibitor. mTOR is a protein involved in the control of many other cell culture processes, including artificial vasculogenesis and cell synthesis, making it a reasonable target for inhibiting tumors with severe angiogenesis. Recently, in reports on the clinical application of multiple technologies involving vascular malformations and refractory vascular tumors, (rapamin) has been proven to have a significant effect in vascular and lymphoproliferative diseases.

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