Will taking crizotinib cause edema?

Crizotinib may cause edema. In clinical application, edema is one of the common adverse reactions of crizotinib. Edema occurs because crizotinib affects some signaling pathways in the body, causing fluid to accumulate in the tissue spaces. Edema caused by this drug is usually mild to moderate and may appear in the patient's legs, hands, abdomen, or face. For the management of edema, doctors often advise patients to limit salt intake and advise patients to drink more fluids to help the body get rid of excess fluid. In addition, doctors may adjust the dose of crizotinib or temporarily discontinue the drug if necessary to relieve edema symptoms. Although crizotinib may cause edema, this side effect can be managed and alleviated in most patients. It is important that patients communicate with their doctors promptly about any discomfort or side effects they experience so that their doctors can take appropriate measures to deal with them and ensure the best possible treatment.