Can Regorafenib be used in combination with PD1?

PD1 usually refers to vascular endothelial growth factor and programmed cell death protein 1, Regorafenib (Regorafenib)It can be used in combination with pd1drugs, and regorafenib can be used in combination with Inhibitors of the PD1 pathway have shown efficacy against a variety of cancers, but the disease-specific and drug-specific benefit mechanisms remain unclear. The efficacy of combined application of regorafenib and PD1 blockade was tested in a mouse hepatocellular carcinoma (HCC) model and was shown to inhibit tumor growth and increase survival by normalizing tumor vasculature and increasing intratumoral CXCR3+CD8 T cell infiltration by increasing CXCL10 expression in HCC cells.