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Pomalidomide’s mechanism of action
Pomalidomide is an analogue of thalidomide with immunomodulatory, anti-angiogenic, and anti-tumor properties. The cellular activity of pomalidomide is mediated through its target protein cereblon, a component of the cullin ring E3 ubiquitin ligase complex. In vitro, substrate proteins are targeted for ubiquitination and subsequent degradation in the presence of drugs, leading to direct cytotoxic and immunomodulatory effects. Pomalidomide inhibits the proliferation of lenalidomide-resistant multiple myeloma (MM) cell lines and synergizes with dexamethasone to induce tumor cell apoptosis in both lenalidomide-sensitive and lenalidomide-resistant cell lines.
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