What does Panitumumab resistance or ineffectiveness mean?

Resistance or ineffectiveness to panitumumab usually means a patient is not responding well to the drug or is no longer responding to it. Drug resistance refers to the fact that tumor cells gradually become resistant to drugs after a period of treatment, causing the drugs to lose their original efficacy. When patients are resistant or ineffective to panitumumab, they usually manifest as tumor progression, disease worsening, or no obvious treatment response. At this point, continued use of panitumumab may no longer be effective, and adjustments to the treatment plan need to be considered. Doctors may perform genetic testing to determine whether there are genetic mutations associated with drug resistance. Based on the test results, they may adjust the treatment plan, such as selecting other targeted drugs, combination treatment strategies, or other treatment methods, in the hope of obtaining better treatment results.