What are the side effects of selumetinib?

Clinical study of selumetinib in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN) The most common adverse reactions (≥40%) were vomiting, rash, abdominal pain, diarrhea, nausea, dry skin, fatigue, musculoskeletal pain, pyrexia, acne, stomatitis, headache, paronychia, and pruritus. Selumetinib may also cause cardiomyopathy, eye toxicity (including retinal vein occlusion, retinal pigment epithelial detachment and visual impairment), gastrointestinal toxicity, skin toxicity, increased creatine phosphokinase, increased risk of bleeding, embryo-fetal toxicity, etc. precautions.