Should Ribociclib be taken before or after meals?

Ribociclib (Ribociclib) Take with hormone (endocrine) therapy. When taking reboxil, patients must swallow the entire tablet with water (do not crush, chew or dissolve) and take it at approximately the same time each day. The official label recommends taking it in the morning. The usual dose is 600 mg. It can be taken with or without food. Riboxiclib is an orally bioavailable, highly selective inhibitor of CDK4/6 kinase with inhibitory IC50 concentrations in the low nanomolar range. After oral administration, reboxiclib is rapidly absorbed with a mean Tmax of 1-5 hours. Due to accumulation, plasma concentrations increased approximately 2-3 times from Day 1 of Cycle 1 to Days 18/21 of Cycle 1, reaching a steady state approximately on Day 8 based on trough concentrations after repeated daily dosing.