The mechanism of action of Semaglutide

Semaglutide in Semaglutide tablets (Semaglutide) is aGLP-1 analogue with 94% sequence homology to human GLP-1. SemaglutideAs a GLP-1 receptor agonist, it selectively binds to and activates the GLP-1 receptor, which is the target of natural GLP-1. GLP-1 is a physiological hormone with multiple effects on glucose mediated by the GLP-1 receptor. Semaglutide lowers blood glucose by stimulating insulin secretion and reducing glucagon secretion, both of which are glucose-dependent. Therefore, when blood sugar is high, insulin secretion is stimulated and glucagon secretion is suppressed. The mechanism of hypoglycemia also involves a slight delay in early postprandial gastric emptying.