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What is the half-life of Sorafenib?
The average elimination half-life of Sorafenib(Sorafenib) is approximately 25-48 hours. Multiple dosing of sorafenib over 7 days resulted in 2.5 to 7 times accumulation compared with single dose administration. Sorafenib inhibits the kinase activity of C-RAF and B-RAF (wild type and V600E mutant). It inhibits MEK and ERK phosphorylation in various cancer cell lines and tumor xenografts and exhibits potent oral antitumor activity in a broad spectrum of human tumor xenograft models. If you want to get more high-quality information, you can contact YaDE. YaDE will do its best to learn more about high-quality overseas drugs for you.
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