How much does a bottle of pemetinib/pemetinib cost in the domestic market?

Pemigatinib (Pemigatinib) is an oral small molecule targeted drug targeting the FGFR (fibroblast growth factor receptor) family, which is an important innovation in the medical field. Rearrangement, amplification or mutation of the FGFR gene plays a key role in a variety of malignant tumors, especially in patients with cholangiocarcinoma (CCA). Pemetinib selectively inhibits the tyrosine kinase activities of FGFR1, FGFR2 and FGFR3 and blocks downstream signaling, thereby inhibiting tumor cell proliferation and angiogenesis and delaying disease progression.

In clinical application, pemetinib is mainly used for advanced or metastatic cholangiocarcinoma, especially patients carryingFGFR2 fusion or rearrangement mutations. For such patients, conventional chemotherapy often has limited efficacy, and pemetinib, as a precise targeted drug, provides a new option for treatment. In addition, pemetinib is also exploring its efficacy in patients with FGFR1 rearrangements in the bone marrow or lymphatic system in some studies, showing potential cross-tumor indication value.

In the domestic market, pemetinib has been approved for marketing, but it has not yet been covered by medical insurance, so the price is relatively high. Common specifications on the market include 4.5mg*14 tablets and 9mg*14 tablets. The price per box is roughly between RMB 20,000 and RMB 50,000. The specific price will fluctuate depending on the region and sales channel. For some patients, this cost burden is greater, but its clinical value and efficacy advantages still make it an important treatment option for patients with high-risk cholangiocarcinoma.

In overseas markets, patients can also choose generic versions of pemetinib. For example, the product produced by Lucius Pharmaceuticals in Laos is 4.5mg*14 tablets, and the price per box is about 700 yuan. Despite the obvious price advantage, you still need to pay attention to drug quality, ingredient consistency, and legal compliance when purchasing.

Reference materials:https://go.drugbank.com/drugs/DB15102