Related introduction of Sebetralstat-Ekterly: What is it a medicine for?

Sebetralstat - Ekterly is an oral plasma kallikrein inhibitor designed for the on-demand treatment of hereditary angioedema (HAE) attacks in adult and pediatric patients 12 years of age and older. HAE is a hereditary disease mainly caused by the deficiency or dysfunction of C1 esterase inhibitory protein (C1INH), resulting in uncontrolled activation of the kallikrein-kinin system. During an attack, patients experience swelling of tissues such as the hands, feet, extremities, face, intestines, and airways, causing significant pain and weakness.

Ekterly's active ingredient, sebetralstat, targets and selectively inhibits plasma kallikrein, thereby intervening in the cascade reaction of the kallikrein-kinin system (KKS) and alleviating the onset of HAE. As the first oral, on-demand treatment for HAE, Ekterly provides a more convenient treatment option. Compared with other treatment options that require intravenous or subcutaneous injection, Ekterly can be taken orally when the early signs of a HAE attack appear.

The FDA's approval was based on the results of a series of clinical trials, particularly data from the KONFIDENT Phase 3 clinical trial and the KONFIDENT-S expansion trial. In Phase 3 trials, sebetralstat's 300mg and 600mg doses were significantly better than placebo in the onset of symptom relief, with the 300mg dose having a median response time of 1.61 hours, compared with 1.79 hours for the 600mg dose and 6.72 hours for placebo, demonstrating its potential for rapid action.

Ekterly tablets should be taken orally at the earliest sign of an acute attack of hereditary angioedema. If symptoms recur, worsen, or feel unwell, patients can take it again at least 3 hours after the first dose to achieve a better therapeutic effect. Although Ekterly is relatively safe to use, some patients may experience common adverse effects such as headache.

In summary,Ekterly (sebetralstat), as an innovative oral treatment option, provides patients with hereditary angioedema with a convenient and effective solution that significantly improves their quality of life.

Reference materials:https://www.ekterly.com/