Latest prices for fezolinetant in 2025

Fezolinetant's primary indication is for the treatment of moderate to severe vasomotor symptoms in postmenopausal women, namely hot flashes and night sweats common in menopausal women. Unlike traditional estrogen drugs, fizonitant works by inhibiting the neurokinin 3 receptor (NK3R), thereby regulating the functional imbalance of the thermoregulatory center in the hypothalamus of the brain. As estrogen levels drop during menopause, the neural regulation of the body temperature center becomes sensitive, causing a sudden increase in blood flow to the body's surface, triggering hot flashes and sweating. Fezonatanteffectively improves this abnormal process by inhibiting the NK3R signaling pathway, making it the world's first non-hormonal therapeutic drug based on this target.

Currently, Fezonatant has been approved for marketing in the United States and Europe under the trade nameVeozah and is sold by Astellas Pharma. The typical specification of this drug is 45mg*30 tablets, taken orally once a day. It is a non-hormonal prescription drug that can be used for a long time. According to overseas market pricing, the price of its original drug is about US$600 per box, equivalent to about more than 3,000 yuan in RMB (the price may be adjusted due to exchange rate fluctuations). For patients who have not yet entered the medical insurance system, the overall cost is higher, but it is still favored by international patients because it can significantly reduce the frequency of menopausal hot flashes and improve sleep quality and life comfort.

In terms of generic drugs, pharmaceutical companies in some Southeast Asian countries, such as Laos, have launched generic versions of Fezonastat containing the same active ingredients. Take the 45mg*30 tablets produced by Lucius Pharmaceutical Factory in Laos as an example. Each box sells for about RMB 900, which is more affordable. This type of generic drugs has the same ingredients as the original drugs, but there are differences in production standards, quality control and drug supervision. Therefore, patients choose regular channels to purchase drugs under the guidance of doctors.

Reference materials:https://www.veozah.com/