Is nintedanib/Vigat a hormonal drug and what are its ingredients?

Nintedanib(Nintedanib) is not a hormonal drug, but a targeted small molecule anti-fibrosis drug. Its active ingredient is Nintedanib Esylate, and its chemical name is [(4-chlorophenyl)([2-[[4-[methyl(phenyl)amino]pyrimidin-2-yl]amino]acetyl]amino)methyl] acetate. Unlike traditional glucocorticoid drugs (such as prednisone and dexamethasone), nintedanib does not work by suppressing the inflammatory response of the immune system, but directly interferes with the formation of pulmonary tissue fibrosis by blocking the signaling of multiple growth factor receptors (VEGFR, FGFR, PDGFR).

From the perspective of its mechanism of action, nintedanib is a "multi-target tyrosine kinase inhibitor". Its main function is to prevent fibroblast proliferation, angiogenesis and collagen deposition, thereby delaying the hardening of lung tissue structure. Because of this difference in mechanism, nintedanib will not cause common side effects of hormone drugs, such as weight gain, osteoporosis or hormone-dependent reactions, and is relatively safe for long-term use.

In terms of preparation ingredients, in addition to active pharmaceutical ingredients, nintedanib capsules also contain conventional excipients, such as microcrystalline cellulose, magnesium stearate and gelatin, to ensure drug stability and bioavailability. Each capsule contains 150 mg of nintedanib acetate, which is a light yellow capsule-like solid.

In summary, nintedanib is a non-hormonal oral targeted drug targeting the mechanism of pulmonary fibrosis and has triple effects of anti-fibrosis, anti-angiogenesis and anti-inflammatory. It represents the transformation direction of modern lung disease treatment from traditional hormone control to precise molecular targeting, and has extremely high clinical application value. With the deepening of research, the indications of nintedanib are constantly expanding, bringing new hope to more patients with interstitial lung disease.

Reference materials:https://en.wikipedia.org/wiki/Nintedanib