Are Lorlatinib and Lorlatinib (Borina) the same drug?

Lorlatinib and lorlatinib (Lorlatinib) are actually different names for the same drug, both referring to third-generation oral tyrosine kinase inhibitors (TKIs) targeting ALK (anaplastic lymphoma kinase)-positive non-small cell lung cancer (NSCLC). In China, the trade name "lorlatinib" is usually used in drug registration and clinical application, while in overseas literature, clinical studies or medical guidelines, Lorlatinib is widely used as an international common name, so the two refer to it exactly the same. There is no difference in the active ingredients, mechanism of action and clinical efficacy of the drugs. It is important to understand this correctly to help avoid patient confusion when purchasing or using medications.

Lorlatinib is a highly effective inhibitor ofALK and ROS1. It is especially suitable for patients who are resistant to first-generation crizotinib or second-generation ceritinib or alectinib treatment. The advantage of third-generation ALK inhibitors is that they can effectively penetrate the blood-brain barrier and are also effective in patients with brain metastases, which is difficult to achieve with early ALK inhibitors. By blocking the ALK downstream signaling pathway, lorlatinib can inhibit tumor cell proliferation and promote apoptosis, thereby controlling disease progression and improving patients' quality of life.

Additionally, lorlatinib is clinically flexible and the oral tablet form facilitates long-term use in outpatient or home settings. In terms of treatment schedule, doctors will make individual dose adjustments based on patient tolerance, imaging results, and concomitant diseases. Whether it is called lorlatinib domestically or lorlatinib abroad, the same targeted efficacy can be obtained. When consulting a doctor or purchasing a drug, patients should make it clear that the two names are the same drug to avoid duplication or confusion and ensure continuity and safety of treatment.

References：https://www.lorbrena.com/