Recommendations for the management of abnormal liver function during treatment with sotoraxib (AMG 510)

During treatment with Sotorasib (Sotorasib), some patients may experience liver function abnormalities, such as elevated serum aminotransferases (ALT, AST) or elevated bilirubin. This situation is mainly related to the effect of drugs on hepatocytes during liver metabolism, and is usually more likely to occur at the beginning of treatment or during the dose adjustment phase. Therefore, regular monitoring of liver function is crucial for early detection and timely treatment of abnormalities.

When blood tests reveal mild liver function abnormalities (such as ALT or AST elevated to the upper limit of normal1 –3 times), usually can be carried out while continuing to observe and maintain the original dose, while strengthening liver function protection measures, such as avoiding alcohol, reducing the combination of hepatotoxic drugs, and regularly reviewing liver function indicators. Most patients with mild abnormalities return to normal within a few weeks without dose adjustment.

If moderate or severe liver function abnormalities occur (ALT or AST increases more than 3 times more than the upper limit of normal, or is accompanied by an increase in bilirubin), the drug should be discontinued immediately and monitored closely, and other possible causes of liver damage, such as viral infection or drug interactions, should be evaluated. Under the guidance of a doctor, you can consider suspending or reducing the dose, restarting treatment after liver function recovers, and make gradual dose adjustments to reduce risks.

In addition, patients should maintain a healthy lifestyle during treatment, avoid high-fat, high-sugar diets and excessive drug use, and promptly report any symptoms such as fatigue, jaundice, loss of appetite, or right upper quadrant discomfort to the doctor. Through standardized monitoring, timely intervention and doctor-patient communication, most sotoraxib-related liver function abnormalities can be effectively managed to ensure the safety and continuity of treatment.

Reference materials:https://www.drugs.com/