What is the approximate cost estimate for one month’s treatment with Seripase (BRINEURA)?

Seripalase (BRINEURA) is an enzyme replacement drug used to treat late-onset neuronal butyrate esterase deficiency (CLN2 disease) in children. It is expensive and has not yet been launched in China. Patients need to purchase it through overseas formal channels. According to current market information, the price of each bottle of 150mg/5ml is USD 16,190.17, and a package of two bottles is priced at USD 32,380.33. This means that the cost of treatment is very high in the short term, putting a greater pressure on the family's financial burden.

The cost of one month's treatment depends mainly on the patient's weight and medication dosage. The use of BRINEURA is usually individualized based on body weight, with intravenous injection once every two weeks, and each dose is related to body weight. If a child of an average weight uses one bottle of medicine, two bottles will be needed per month, which means the monthly treatment cost is approximately US$32,380, not including possible shipping costs and additional costs for overseas purchasing channels.

Considering the need for long-term treatment, patients with CLN2 disease may need to continue receiving BRINEURA for months or even years. Therefore, families need to plan ahead when it comes to their budgets and consider applying for health insurance coverage, patient assistance programs, or charitable funds to alleviate financial stress. Patients and their families should maintain close communication with doctors, pharmacists and overseas drug supply channels to ensure the continuity and safety of medication.

In general, although BRINEURA has significant clinical effects on CLN2 disease, its high price and the fact that it cannot be purchased directly in China make the cost of treatment a key issue that families must consider. Reasonable planning of funds, evaluation of assistance channels and scientific arrangement of treatment courses are the keys to ensuring that patients can continue to receive effective treatment.

Reference materials:https://www.drugs.com/