What is the chemical formula of pomalidomide?

Pomalidomide (Pomalidomide) is an immunomodulator derived from the structural modification of thalidomide. Its chemical formula is C₁₃H₁₁N₃O₄ and its molecular weight is approximately 273.25. It belongs to the thienopyridine derivatives. By introducing specific substituents on the parent molecule, the bioavailability and anti-tumor activity of the molecule is improved. The structural feature of pomalidomide is that it retains the core ring structure of thalidomide and modifies the adjacent position, making it more targeted and metabolically stable in immune regulation and anti-cancer mechanisms. From a chemical point of view, the molecule of pomalidomide contains indolinone and phthalimide structures. This unique configuration is the key to its binding to intracellular proteins.

In terms of pharmacological mechanism, pomalidomide binds to the CRBN protein in theE3 ubiquitin ligase complex, which promotes the degradation of a variety of transcription factors related to tumor cell growth (such as Ikaros and Aiolos), thus blocking the proliferation of malignant plasma cells. In addition, it can also regulate the function of the immune system, enhance the activity of T cells and natural killer cells, and further improve the anti-tumor immune response. For this reason, pomalidomide is not only a molecule with a unique chemical structure, but also represents a model for the precise design of a new generation of immunomodulators at the molecular level.

In clinical application, pomalidomide has become an important therapeutic drug for relapsed or refractory multiple myeloma (MM). Compared with lenalidomide, its molecular structure optimization makes the efficacy more durable and the side effects more controllable. Currently, its chemical information and synthetic routes have been included in the pharmacopoeias of many countries, providing researchers with a reference for further development of improved derivatives. Overall, although the chemical formula of pomalidomide is simple, the molecular configuration design behind it reflects the high degree of innovation of modern medicinal chemistry in the field of anti-cancer, and also indicates the broad potential of immunomodulatory drugs in future precision medicine.

Reference materials:https://en.wikipedia.org/wiki/Pomalidomide