Main contraindications and precautions for mirikizumab

Milikizumab (Mirikizumab) has clear contraindications and precautions in clinical application to ensure the safety of the drug. First of all, patients known to be allergic to militizumab or any of its excipients are prohibited from using it, and its use may lead to severe allergic reactions or anaphylactic shock. In addition, because this drug is an immunosuppressive biologic, it should be avoided in patients with active severe infection or uncontrolled tuberculosis infection to prevent aggravation of the infection. Caution is also required before and after vaccination with live vaccines because biologics may reduce vaccine effectiveness or increase vaccine-related risks.

In terms of precautions, militizumab may suppress the immune system during use, so patients should regularly monitor blood routine and liver function, and pay attention to early symptoms such as upper respiratory tract infection and urinary system infection. For patients with a history of hepatitis virus infection or chronic liver disease, virological monitoring is required to avoid the risk of potential reactivation. For pregnant and lactating women, there is currently a lack of sufficient safety data, so it is generally recommended to use it with caution only when the potential benefits clearly outweigh the risks, and to consult a professional doctor before use.

At the same time, since militizumab is administered intravenously or subcutaneously, redness, swelling, itching or mild pain may occur at the injection site, and it is necessary to operate it correctly and keep the injection site clean. Patients should avoid combined use with other immunosuppressive drugs during treatment to reduce the risk of infection or excessive immunosuppression. Regular colonoscopy review and clinical evaluation are crucial to judge efficacy and safety. Doctors can adjust the maintenance dose or extend the injection interval according to the condition.

In summary, the main contraindications for militizumab include patients with drug allergies and active infections, and the precautions for use include infection monitoring, liver function assessment, vaccination and pregnancy and lactation management.

Reference materials:https://omvoh.lilly.com/