Lorlatinib/lorlatinib box price reference list

Lorlatinib/ Lorlatinib ( Lorlatinib), as a new generation of ALK/ROS1 targeted inhibitor, has attracted great attention in global clinical applications due to its drug resistance coverage and central nervous system penetration advantages. Compared with early ALK inhibitors, the core concept of lorlatinib's research and development is to "break through drug resistance, strengthen the control of brain metastases, and prolong the stable period of the disease." This design enables it to target resistance mutations that appear after a variety of second-generation ALK inhibitors, especially in the control of brain metastases, showing significant advantages, and is therefore regarded as one of the important options for late-line treatment in international guidelines.

For patients with non-small cell lung cancer who have received crizotinib, alectinib, brigatinib and other drugs but have experienced disease progression, lorlatinib is often used as a key follow-up regimen. Its value lies not only in continuing treatment options, but also in improving quality of life and long-term stability.

As for the price, the domestic original drug is marketed as "lorlatinib tablets" and has been included in Class B medical insurance reimbursement, which means that the actual burden on patients has dropped significantly compared with the past. Common specifications include 25mg 90 tablets and 100mg 30 tablets. The price per box without reimbursement is about 20,000 yuan, and the price after medical insurance will further drop due to different regional policies.

In Hong Kong, China, the market price of the original version of lorlatinib is approximately RMB 30,000 to RMB 50,000, depending on procurement channels and specifications. In some overseas markets, such as Türkiye, you can also find official original drugs, and the price of 30 tablets of 100 mg is about 10,000 yuan. For patients who are more sensitive to the financial budget, there are also reliable quality generic drugs on the market to choose from. For example, the 100mg 30 tablets produced by a Lao pharmaceutical factory cost around 1,000 yuan. However, it is important to note that changes in international exchange rates will affect the final cost.

References：https://www.lorbrena.com/