Mirikizumab injection methods and operating techniques

Mirikizumab can be administered via intravenous injection or subcutaneous injection in clinical use. The strategy of “first 3 intravenous injections, then subcutaneous injection every 4 weeks” is followed in the early stage of treatment, so that the drug can quickly reach an effective concentration and remain stable during the maintenance period. Patients usually complete their first subcutaneous injection in a hospital or doctor's office, and only after receiving professional guidance can they operate a prefilled pen or prefilled syringe at home.

Before using it at home, you need to read the instructions carefully and be guided by a doctor or nurse. Do not increase or decrease any dose on your own. Use each prefilled pen or syringe only once. Make sure to dispose of the complete solution in a puncture-proof recycling container and ask your doctor or pharmacist how to dispose of the container.

Injection site selection is critical. The front thigh or abdomen (avoiding the area within 5 cm around the navel) are commonly used sites. If someone else is doing the injection, the outside of the upper arm can be chosen. In order to reduce local redness, swelling and pain, the site of each injection must be changed, and injections must not be made in areas of redness, damage, induration, scars or stretch marks. A full dose usually requires the use of two pens or syringes, and two consecutive injections are required to ensure a complete and accurate dose.

Medicines taken out of the refrigerator need to warm naturally: about 30 minutes for prefilled pens and 45 minutes for prefilled syringes. Do not use microwaves, hot water or other heating methods as this may damage the structure of the drug. Do not shake the device during the heating process, and do not remove the protective cover in advance; it can only be removed before the actual injection, and the cover must not be put back on once removed.

If the equipment is dropped or damaged and cannot be used anymore, it should be replaced with a new one. The entire process needs to be kept robust and clean to avoid contaminating the injection needle. If the patient is unfamiliar with the injection procedure, the medical team can demonstrate or practice the procedure again.

Reference materials:https://omvoh.lilly.com/