Why should you eat as little as possible of Ribociclib/Calilon?

Ribociclib/Calilon (Ribociclib), as a CDK4/6 inhibitor, is one of the more targeted drugs used in the treatment of breast cancer in recent years. When many patients hear "eat as little as possible", they often misunderstand that the drug itself cannot be used for a long time, but in fact what really needs to be paid attention to is the combination of diet and possible interactions between drugs and food. Riboxiclib is mainly metabolized by the liver enzyme system in the body, and certain foods can affect this metabolic process, causing the blood concentration of the drug to increase or decrease abnormally. Therefore, doctors will remind patients to avoid "eating at will" while taking the drug, especially to avoid risky foods that can interfere with metabolism.

Among them, the most typical one is grapefruit and related products, because grapefruit can inhibit the enzyme activity of CYP3A4 and reduce the metabolism rate of reboxiclib, which may lead to increased drug exposure in the body and increase the probability of adverse reactions. Likewise, high-fat foods or stimulating diets may also affect gastrointestinal absorption. Although this type of effect is weaker than that of grapefruit, it may still fluctuate in sensitive patients. Therefore, it is usually recommended to maintain a relatively regular and light diet during medication. For some patients with weak constitution and low liver function, if they consume a large amount of greasy or indigestible food after taking the medicine, it may increase the burden on the gastrointestinal tract, make nausea, bloating and other discomforts more obvious, and also affect the patient's ability to adhere to the treatment course.

In addition, "try to eat as little as possible" also means avoiding excessive intake of supplements or medicated foods when Riboxil causes a decrease in white blood cells and an increase in liver enzyme indicators. During the medication period, patients should try to follow a fixed medication time, a normal eating rhythm, and not blindly increase food intake. This is also to help the body better adapt to the rhythm of drug metabolism and reduce side effects caused by fluctuations in drug concentration.

Reference: https://us.kisqali.com/