Why shouldn’t you take Tofacitinib/Shangjie at night?

Tofacitinib/Shangjie(Tofacitinib) is a JAK inhibitor drug, mainly used to treat immune diseases such as rheumatoid arthritis and psoriatic arthritis. Tofacitinib slows down the immune response by interfering with the JAK signaling pathway, thereby reducing inflammation and tissue damage. Although it is highly effective in treating these diseases, when using it, patients often face the problem of taking the medication correctly.

Why should not tofacitinib be taken at night? This problem is related to the pharmacokinetic characteristics of the drug and the effect of the drug on the human body. First, tofacitinib is somewhat irritating, especially in the gastrointestinal tract. Patients may experience stomach upset, nausea, diarrhea and other symptoms after taking this drug. If taken at night, because people are less active at night and the motility function of the gastrointestinal tract is relatively slow, this may aggravate the side effects of the drug, making the patient unbearable discomfort at night and affecting sleep quality.

Secondly, tofacitinib has a strong inhibitory effect on the immune system. After taking it, it will inhibit the inflammatory response in the body and may also reduce the activity of the immune system. This inhibitory effect is particularly obvious during sleep. Therefore, some patients may experience fatigue or discomfort after taking the drug at night, which affects their daily activities the next day.

To avoid these adverse reactions, experts usually recommend that patients take tofacitinib during the day, especially in the morning or noon, which can ensure better absorption of the drug and reduce discomfort caused by drug side effects. When taking it during the day, patients can also eat some food to reduce the occurrence of gastrointestinal discomfort. In addition, maintaining a regular schedule and moderate exercise can also help improve the metabolism of drugs, thereby improving the therapeutic effect.

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