What is the real weight loss effect of Semaglutide Injection?

Semaglutide injection (Wegovy) is a glucagon-like peptide-1 (GLP-1) receptor agonist that has been widely used for weight management in obese and overweight patients (obesity). Its main mechanism of action is to help patients achieve weight loss by simulating the physiological effects of GLP-1 hormone, delaying gastric emptying, enhancing satiety, suppressing appetite, and improving energy metabolism and blood sugar homeostasis. Semaglutide needs to be combined with a low-calorie diet and increased physical activity to achieve full efficacy.

Real-world data shows that semaglutide can significantly reduce body weight in a variety of populations. Adult obese or overweight patients can reduce their average weight by about 15% after long-term use of semaglutide. For obese patients with cardiovascular disease, its use not only helps to lose weight, but also reduces the risk of major cardiovascular events, such as myocardial infarction, stroke and cardiovascular death. Children and adolescent patients can also achieve weight control and long-term maintenance goals through moderate use, especially for patients 12 years old and above with obvious weight-related symptoms.

The weight loss effect of semaglutide is not only reflected in the reduction of total weight, but also includes the improvement of body fat percentage, waist circumference reduction and visceral fat reduction, which is of great significance in improving obesity-related metabolic risks. During use, patients usually need to go through a dose escalation period to reduce gastrointestinal side effects, combined with a healthy diet and regular exercise to maintain long-term weight stability. Overseas guidelines emphasize that the sustainability of weight loss results depends on a combination of long-term treatment and lifestyle intervention. Once the medication is stopped, weight may rebound, so individualized maintenance treatment is very critical.

In summary, semaglutide injection has demonstrated significant weight loss effects in the real world, and is especially suitable for adults and some adolescent patients who are obese, overweight, and associated with cardiovascular risks.

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