The three most taboo foods when taking brigatinib/brigatinib (Embry)

Brigatinib/Brigatinib (Brigatinib) is a targeted drug that works by blocking the ALK signaling pathway. Its absorption and metabolism are closely related to dietary habits. In order to reduce interference between drugs, there is a clear summary of "taboo foods" in the medication guide. Although not absolutely taboo, the following three types of foods are generally considered to be avoided or reduced as much as possible to avoid affecting the efficacy of the medicine or increasing discomfort.

The first is high fructose-citrus fruits, such as grapefruit, pomelo, orange derivatives, etc. This type of food can interfere with the liver metabolic enzyme system, causing the concentration of brigatinib to increase in the body or slowing down the metabolism, which may increase the risk of discomfort. Due to its extensive and unpredictable interference, grapefruit is usually listed as the main taboo target of targeted drugs. The key to maintaining stable drug efficacy is to avoid its impact on the enzyme metabolism system, so patients should actively avoid related juices, jams and drinks containing extracts.

The second category is high-fat and high-oil foods, such as fried foods, creamy desserts or high-fat meats. Brigatinib can be taken with food or on an empty stomach, but excessive fat intake will affect the absorption rate of the drug and may cause fluctuations in blood drug concentration, thereby affecting tolerance and medication experience. For patients with a sensitive gastrointestinal tract, a high-fat diet is more likely to cause digestive discomfort, making the experience of taking medication difficult. Maintaining a light and easy-to-digest diet will help stabilize the gastrointestinal tract and maintain regular absorption.

The third category includes alcoholic drinks and irritating spices, including liquor, beer, spirits, and foods containing a large amount of irritating spices. Alcohol increases the metabolic burden on the liver and has overlapping metabolic pathways with brigatinib, which may affect the drug clearance rate. At the same time, alcohol may aggravate fatigue, headache or stomach discomfort, and affect patients' judgment of drug side effects. If you need to drink alcohol, consult your doctor in advance and try to reduce your intake as much as possible.

Reference materials:https://www.alunbrig.com/