What are the contraindications of Ruxolitinib Tablets/Jiekewei?

Ruxolitinib tablets/Ruxolitinib (Ruxolitinib) is aJanus kinase (JAK) inhibitor, mainly It is used to treat primary myelofibrosis (PMF), myelofibrosis secondary to polycythemia vera (PPV-MF), acute graft-versus-host disease (GVHD) and other diseases. By inhibiting the JAK-STAT signaling pathway, ruxolitinib can effectively reduce the proliferation of abnormal blood cells, thereby improving symptoms of related diseases and patients' quality of life.

However, despite its clinically significant efficacy, ruxolitinib also has certain contraindications. When using ruxolitinib, the following types of patients should avoid using the drug or need to use it under the strict guidance of a doctor:

1. Patients with known hypersensitivity to ruxolitinib or any of its components: If patients have an allergic reaction to ruxolitinib or any of its components, including rash, difficulty breathing, or severe allergic reaction, they should avoid using this drug.

2. Patients with severe hepatic dysfunction: The metabolism of ruxolitinib is mainly carried out through the liver. Therefore, patients with severe hepatic dysfunction, especially Child-Pugh class C patients, may cause drug accumulation in the body when using ruxolitinib, increasing the risk of drug toxicity and side effects. In this situation, ruxolitinib must be avoided.

3. Patients receiving strong CYP3A4 inhibitors: The metabolism of ruxolitinib is closely related to the CYP3A4 enzyme. Therefore, in patients using strong CYP3A4 inhibitors, the blood concentration of ruxolitinib may be too high, increasing the side effects of the drug. Concomitant use of ruxolitinib should be avoided in such patients.

4. Patients with severe immune system deficiency: Because ruxolitinib has an immunosuppressive effect and may lead to impaired immune system function, patients with severely compromised immune systems, such asHIV/AIDS patients, should avoid using this drug.

Before using ruxolitinib, patients must report their past medical history and existing diseases to their doctor in detail, ensure there are no contraindications, and obtain professional guidance.

Reference materials:https://www.jakavi.com/