Does Apremilast (Otelor) cause gastrointestinal discomfort and how to deal with it

Apremilast (Apremilast) is an oral phosphodiesterase 4 (PDE4) inhibitor, mainly used to treat moderate to severe psoriasis and psoriatic arthritis. The drug regulates intracellular cAMP levels and inhibits the production of pro-inflammatory cytokines, thereby alleviating inflammatory reactions and skin and joint symptoms. Although generally well tolerated, gastrointestinal discomfort is one of the most common adverse reactions and patients need to pay attention during use.

Gastrointestinal reactions are mainly manifested as nausea, diarrhea, abdominal pain and loss of appetite. They usually appear at the beginning of medication and usually resolve gradually within a few weeks. These reactions are related to the effects of drugs on gastrointestinal smooth muscle and neural regulation. Most patients can reduce symptoms with appropriate lifestyle modifications and medication management without discontinuing medication.

To relieve gastrointestinal discomfort, patients can take the medicine with meals or in divided doses, while ensuring that the diet is light and less greasy. If diarrhea occurs, add appropriate amounts of water and electrolytes to avoid dehydration. In case of mild nausea, anti-nausea drugs can be used under the guidance of a doctor or the medication time can be adjusted, such as taking it after breakfast or dinner.

In addition, if gastrointestinal discomfort persists or worsens, you should contact your doctor promptly. Doctors may adjust the dose, extend the dose escalation cycle, or give symptomatic treatment based on symptoms. In most cases, with proper management and monitoring, patients can continue to use apremilast and achieve stable efficacy, while gastrointestinal discomfort will gradually alleviate without affecting long-term treatment.

Reference materials:https://www.drugs.com/