How long does it take for Entrectinib/Luoshengquan to take effect?

Entrectinib (Entrectinib) has become a precision treatment drug that has attracted much attention in recent years because of its ability to be used for both ROS1-positive metastatic non-small cell lung cancer and adult and pediatric solid tumor patients carrying NTRK gene fusions. One of the biggest concerns many patients have after starting to take it is "how long will it take to see the effects". Judging from global experience, the onset of action of entrectinib has certain rules, but is closely related to individual differences.

Generally speaking, the onset of effect of entrectinib is not instantaneous, but gradually appears after continued use. Most patients will experience subtle changes in their physical condition in the first few weeks, such as easier breathing, reduced pain, improved physical fitness, etc. These are the initial reactions after the drug inhibits the activity of cancer cells. It usually takes longer for imaging to actually show tumor changes, because there is often a certain delay in tumor size reduction or decrease in activity. This is a phenomenon that has been generally verified in clinical observations around the world.

The onset of action of entrectinib is closely related to its mechanism of action. The drug specifically targets ROS1 or NTRK fusion, blocks tumor growth signals, reduces tumor cells' dependence on the proliferation pathway, and gradually loses their ability to expand. For ROS1-positive lung cancer patients, if the tumor involves the chest, mediastinum or central location, symptom improvement is often more intuitive. Many patients will feel a decrease in respiratory pressure in the early stages of treatment, which is an actual manifestation of the drug's effect.

For patients with solid tumors with NTRK fusions The tumor types and locations vary greatly, and the response time also varies. In central nervous system tumors, soft tissue tumors, children's tumors and other groups, entrectinib can penetrate the blood-brain barrier and may have a faster onset of effect in some cases. Patients can experience improvements in neurological function, pain or physical fitness earlier.

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