Study on the Effect of Febuxostat/Febuxonide on Creatinine Levels

Febuxostat is a xanthine oxidase (XO) inhibitor widely used to treat gout caused by hyperuricemia. By lowering blood uric acid levels, febuxostat effectively relieves gout symptoms and uric acid-related complications. However, as a drug used to treat chronic hyperuricemia, the effect of febuxostat on renal function, especially creatinine levels, has become an important issue of concern to the medical community.

Creatinine is an important kidney function marker, often used to evaluate renal tubular filtration rate (GFR) and kidney health. With the use of febuxostat in patients with gout and hyperuricemia, researchers have begun to explore the drug's potential effects on creatinine levels. Multiple clinical studies have shown that febuxostat has a milder effect on renal function than allopurinol. Especially in long-term use, febuxostat has a more significant protective effect on renal function.

Specifically, some studies suggest that febuxostat's effect on creatinine levels is limited. After a period of use, patients' creatinine levels usually remain stable without significant increases. Compared with allopurinol, febuxostat appears to place less burden on the kidneys while lowering uric acid, especially in patients with already mildly impaired renal function. Based on these study data, febuxostat is considered a relatively safe treatment option, especially for patients who are intolerant or have poor response to allopurinol.

However, some studies indicate that febuxostat may cause a slight increase in creatinine levels in certain high-risk patients, especially those with pre-existing renal impairment. In this regard, creatinine levels are monitored regularly to ensure that renal function does not deteriorate further during treatment. In addition, for patients with severely impaired renal function, caution should be used when using febuxostat, and the dose should be adjusted or other treatment options considered based on the patient's specific conditions.

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