Side effects of dupilumab/dalbitux as biologics

Dupilumab (dupilumab) is a biological agent that targets the immune system and can effectively treat atopic dermatitis, asthma and other immune-mediated diseases. Although dupilumab has shown excellent efficacy in many clinical trials and practical applications, as a biological agent, it still has certain side effects. Patients should fully understand these risks when receiving treatment and perform necessary monitoring during the treatment process.

The side effects of dupilumab mainly include local reactions, eye symptoms and allergic reactions. Local reactions are one of the most common side effects, and patients may experience redness, swelling, pain, or itching at the injection site. Although these reactions are usually mild, if symptoms persist or worsen, patients should consult a doctor promptly and take appropriate treatment measures.

Eye symptoms are also one of the more common side effects of dupilumab. Some patients may experience symptoms such as conjunctivitis, itchy eyes, and eye congestion during treatment. These symptoms are usually mild, but if symptoms are not relieved or interfere with the patient's daily life, the doctor may recommend adjustments to the treatment plan or symptomatic treatment.

In addition, allergic reactions are also a potential side effect of dupilumab treatment. Although allergic reactions are rare, some patients may experience allergic symptoms such as rash and difficulty breathing. In this case, the patient should stop taking the medication immediately and seek medical help. For patients with a history of allergies, they should fully inform their doctor before use and maintain close observation during treatment.

Although the side effects of dupilumab are relatively mild, certain immune-related adverse reactions such as cytokine release syndrome (CRS) may affect the patient's treatment process. CRS is a series of symptoms caused by excessive activation of the immune system, usually manifesting as fever, hypotension, fatigue and other symptoms. Fortunately, this side effect is rare in the clinic and can be effectively managed by adjusting dosage or suspending treatment.

Reference materials:https://www.dupixent.com/