Interactions between dacomitinib/dacomitinib (Dozerun) and food

Dacomitinib (Dacomitinib) is a targeted drug. Its interaction with food is mainly reflected in its interaction with certain foods and herbs, especially with grapefruit and St. John's wort, which may affect the metabolism and serum concentration of the drug.

First of all, grapefruit and its products have a significant impact on dacomitinib. Certain chemical components contained in grapefruit can inhibit the activity of CYP3A4 enzyme. CYP3A4 is an enzyme in the liver responsible for metabolizing many drugs, including dacomitinib. If you consume grapefruit while taking dacomitinib, it may cause high concentrations of the drug in your body, increasing your risk of adverse reactions. Therefore, in order to ensure the efficacy of dacomitinib and reduce the occurrence of adverse reactions, it is recommended that patients with non-small cell lung cancer avoid eating grapefruit or its products while taking this drug.

Secondly, St. John's wort, an herb commonly used to treat depression and anxiety, may affect the metabolism of dacomitinib. St. John's wort accelerates the metabolism of dacomitinib by inducing the activity of CYP3A4 enzyme, which may reduce the serum concentration of dacomitinib and weaken the drug effect. To avoid this, patients should avoid taking St. John's wort while taking dacomitinib or discuss with their doctor whether other medications can be safely used in combination with it before use.

In addition, the interaction between dacomitinib and antacids is also an issue that patients need to pay attention to. Antacids may affect the acid environment of the stomach, thereby affecting the absorption of dacomitinib. To avoid this, patients should ensure that they take dacomitinib at least 6 hours before or 10 hours after taking an antacid.

In order to ensure the stable effect of dacomitinib and reduce drug interactions, patients should try to take the drug at the same time every day, follow the doctor's recommendations, and avoid using it at the same time with other foods or drugs that may interfere with drug metabolism.

Reference materials:https://www.pfizer.com/products/product-detail/vizimpro