What are the specific effects and side effects of enzalutamide/enzalutamide (Encotan)?

Enzalutamide/Enzalutamide ( Enzalutamide) is an androgen receptor inhibitor widely used in the treatment of prostate cancer. It blocks the activity of androgen receptors and inhibits the promotion effect of androgens (such as testosterone) on prostate cancer cells, thereby inhibiting the growth of cancer cells. Enzalutamide can not only slow down the progression of cancer, but also prolong the survival of patients, especially in the treatment of castration-resistant prostate cancer and metastatic prostate cancer.

The main effect of enzalutamide is to inhibit the transcriptional activity of androgen receptors and prevent androgens from binding to the receptors, thereby reducing the proliferation of tumor cells. It is particularly effective in the treatment of castration-resistant prostate cancer (CRPC) and metastatic castration-sensitive prostate cancer. Studies have shown that enzalutamide can significantly improve the progression-free survival (PFS) and overall survival (OS) of patients, and can effectively reduce the tumor metastasis rate in patients with metastatic prostate cancer. Especially when combined with other drugs (such as chemotherapy, other androgen suppressing drugs), the therapeutic effect of enzalutamide is more obvious.

In addition, enzalutamide also has positive clinical performance in the treatment of biochemical recurrence (PSA elevation) or high-risk non-metastatic castration-sensitive prostate cancer. It can delay the progression of the disease, reduce the growth of cancer cells, and even improve the patient's quality of life by inhibiting the activation of androgen receptors.

Although enzalutamide is highly effective, it may also cause certain side effects. The most common side effects include: fatigue, high blood pressure, hot flashes, neurological symptoms, digestive system reactions, reduced bone density, rash, and allergic reactions; the side effects of enzalutamide are relatively controllable, and most side effects can be relieved as treatment continues. Patients should undergo regular examinations during treatment, pay close attention to possible side effects, and promptly consult their doctor to adjust the treatment plan when discomfort occurs.

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