Which drugs can be used in combination with Bikeren Pronol Tablets (Bituowei) and precautions

Biktarvy (Biktarvy) is a single-tablet compound triple regimen, which already contains bictegravir (BIC), emtricitabine ( pan>FTC) and tenofovir disoproxil (TAF) themselves constitute a complete antiviral treatment regimen, so Usually there is no need to combine it with other anti-HIV drugs. However, in some special clinical situations, such as coinfections, accompanying diseases or the need for special drug treatment, Biktarvy can be used in combination with some non-anti-HIV drugs, but drug interactions must be paid attention to.

When combined with opportunistic infections (such as Pneumocystis pneumonia, fungal infection, tuberculosis, etc.), Biktarvy can be used in combination with anti-infective drugs, such as compound sulfamethoxazole (SMZ/TMP), fluconazole, amphotericinB, etc. However, some drugs, such as rifampicin, rifabutin, carbamazepine, which strongly induce CYP3A and P-gp, will significantly reduce the concentration of bictegravir, resulting in a decrease in antiviral effect. Therefore, combined use should be avoided or the regimen should be adjusted after the doctor monitors the blood concentration.

For patients with long-term chronic diseases, if they must take lipid-lowering drugs, antidepressants, gastric drugs or antihypertensive drugs at the same time, Biktarvy is generally relatively safe, but some drugs still require caution. For example: antacids containing magnesium, aluminum, and calcium may affect the absorption of biktegravir, so it is recommended to take them at intervals with Biktarvy; high-dose atorvastatin or rosuvastatin may increase the risk of myotoxicity; anti-epileptic drugs such as phenytoin and phenobarbital may also reduce the efficacy of antiviral drugs, and a doctor's evaluation is required before deciding whether to use them together.

In general, BiktarvyAlthough there are relatively few drug interactions, as the core program of antiviral treatment, any combination of drugs must ensure that it does not affect the blood concentration and efficacy of the drug. Patients should consult a doctor or pharmacist in advance before starting any new medicines, health products, or herbal medicines. In particular, they should avoid taking highly inducing drugs on their own to avoid virus "breakthrough" and drug resistance. Reasonable medication management can ensure that treatment remains effective and minimize the risk of adverse reactions and reduced efficacy.

Reference materials:https://www.drugs.com/

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