Is neratinib/neratinib (He Li'an) harmful to the body?

Neratinib/Neratinib (Neratinib), as a targeted therapy drug, is mainly used to treat HER2-positive breast cancer, especially for patients who are ineffective in traditional treatments such as Herceptin (trastuzumab). Although neratinib has a significant inhibitory effect on tumor cells, it also has certain side effects and potential damage to the body. Therefore, patients need to pay attention to and monitor the body's response during use.

First of all, common side effects of neratinib include diarrhea, nausea, loss of appetite, fatigue, headache, etc. Diarrhea is one of the most common side effects. Most patients will experience diarrhea symptoms in the early stages of use. Although this adverse reaction can be alleviated through drug adjustment and symptomatic treatment, long-term use may affect the patient's quality of life. If diarrhea is not controlled in time, it may lead to problems such as loss of body fluids, electrolyte imbalance, and malnutrition. Therefore, during the treatment process, patients should pay close attention and communicate with their doctors, and take diarrhea drugs and rehydration treatment if necessary.

Secondly, neratinib may also cause liver function damage, especially the increase in liver enzymes (ALT, AST). Abnormal liver function is a problem that requires special attention during neratinib treatment. Therefore, patients should undergo regular liver function tests during treatment to ensure that the impact of the drug on the liver is within a controllable range. In some cases, if serious adverse reactions occur in liver function, doctors may adjust the drug dosage or suspend treatment based on the patient's specific conditions.

Although neratinib carries some risk of side effects, it does not cause more extensive damage to the body than traditional chemotherapy drugs. Compared with chemotherapy, targeted therapy drugs usually have a clear targeting effect and can accurately inhibit the growth of tumor cells, thereby reducing damage to normal cells. Therefore, although neratinib may cause some side effects, overall it does relatively little damage to the body, and most side effects can be alleviated with appropriate treatment.

Reference materials:https://en.wikipedia.org/wiki/Neratinib