Common side effects and precautions of Semaglutide Injection

In the field of weight management (obesity) and metabolic disease treatment, semaglutide injection (Wegovy) has attracted attention because it regulates appetite and energy intake by simulating the effects of GLP-1 receptors.但在临床应用过程中，充分了解其可能带来的不良反应及用药安全要点，是保障治疗获益的重要前提。相较于单纯关注减重效果，系统认识风险、加强监测与个体化管理，更符合当前国际用药共识。

从临床研究和上市后监测来看，司美格鲁肽在部分患者中可能诱发急性胰腺炎。 Once persistent and severe upper abdominal pain occurs, accompanied by nausea, vomiting and other symptoms, you should be highly vigilant about pancreatic-related problems, discontinue medication promptly and receive medical evaluation.如果最终明确为胰腺炎，通常不建议再次使用该药物，以避免风险重复发生。 At the same time, gallbladder system events have also been observed in the study, especially in people who lose weight more quickly, and the probability of gallstones or cholecystitis may be increased.因此，出现右上腹不适、消化异常时，应进行针对性的影像学检查并随访处理。

低血糖风险主要集中在合并使用胰岛素或促胰岛素分泌类药物的患者。司美格鲁肽本身引发严重低血糖的概率较低，但联合治疗时可能放大这一风险。 Clinically, it is usually necessary to adjust the original blood sugar-lowering plan according to blood sugar changes, and clearly explain the early signs of hypoglycemia to patients, such as palpitations, sweating, dizziness or confusion, so that timely intervention can be achieved.

In terms of renal safety, individual patients may develop secondary acute renal damage after experiencing obvious gastrointestinal reactions (such as frequent vomiting, diarrhea), especially those with preexisting renal insufficiency.因此，在治疗初期及剂量逐步增加阶段，定期评估肾功能指标，有助于降低潜在风险。若出现尿量减少或水电解质紊乱迹象，应尽快就医。

此外，上市后资料提示，少数患者可能发生过敏相关反应，包括皮疹、呼吸困难甚至血管性水肿。一旦怀疑为药物超敏反应，应立即停止用药并接受对症治疗。 Forpatients with type 2 diabetes, they also need to pay attention to changes in the fundus condition. Some studies have reported that it may be related to the progression of diabetic retinopathy. Those with a related history should strengthen ophthalmological monitoring.

在心血管和精神心理层面，司美格鲁肽可能导致心率轻度升高，因此建议在长期使用过程中进行规律监测。 At the same time, individual patients have reported mental symptoms such as depression and suicidal ideation, especially those with depression tendencies or a history of mental illness. They should pay close attention to changes in their mental state during medication. If abnormalities occur, the medication should be discontinued in time and professional help should be sought.

In terms of contraindications, semaglutide is generally not suitable for people who have been diagnosed with medullary thyroid cancer (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN2), as well as those with related family history. In addition, patients with a known history of allergy to the active ingredients or any excipients of this product should avoid use.

Reference materials:https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ee06186f-2aa3-4990-a760-757579d8f77b