What should I do if I become resistant to tepotinib?

Tepotinib's main functions include inhibiting MET receptor kinase activity and blocking the effect of MET fusion genes, thereby interfering with the growth, proliferation and metastasis of cancer cells. This makes it a potential treatment for patients with non-small cell lung cancer (NSCLC) who have MET fusion genes.

MET receptor is an important cell surface receptor that participates in signaling pathways that regulate the growth, proliferation and migration of various cells. In some tumors, MET receptors may be overactivated or produce abnormal mutations, promoting the malignant transformation and spread of cancer cells. Tepotinib blocks the transmission of abnormal MET signaling pathways by binding to the MET receptor and inhibiting its kinase activity, which helps inhibit the growth, proliferation and metastasis of cancer cells. Tepotinib can target the abnormal products of these MET fusion genes, thereby weakening or eliminating the abnormal proliferation ability of cancer cells. Everyone’s constitution is different and their resistance to drugs is also different. If you feel unwell, please inform your doctor in time.

The original drug Tepotinib is a new type of drug that has not yet been marketed in China, so it has not been included in the medical insurance. Domestic patients cannot yet purchase this drug in pharmacies or hospitals. The price of Tepotinib's original drug specification 225mg*30 tablets per box is around RMB 80,000 per box (the price may fluctuate due to exchange rate effects). It has been on the market for a short time and is expensive. There are also generic Tepotinib drugs produced in other countries. The price of a box of 225mg*60 tablets produced by a Lao pharmaceutical factory is around RMB 8,600 (the price may fluctuate due to the exchange rate). The ingredients of generic drugs produced abroad are basically the same as those of the original drug. For specific prices and drug details, please consult Yaode’s medical consultant.