Domestic price of tepotinib

Tepotinib (tepotinib), as a tyrosine kinase inhibitor (TKI), has the ability to highly selectively inhibit the activity of MET receptor kinase. MET is a receptor tyrosine kinase involved in regulating a variety of cellular functions, including cell proliferation, survival, migration, and invasion. Innon-small cell lung cancer,MET may be overactivated or mutated, resulting in abnormal MET signaling, thereby promoting the malignant transformation and spread of cancer cells.

In non-small cell lung cancer(NSCLC), some signaling pathways and specific oncogenes are deregulated and are known to affect changes associated with tumorigenesis, including apoptosis, proliferation, cell cycle progression, and gene expression. In tumors with MET fusion genes, the MET gene fuses with other genes to form abnormal genes, which can lead to an overactive MET signaling pathway. Tepotinib is usually an oral tablet taken once daily with food. Patients can take tepotinib at about the same time each day and do not take more or less often than prescribed by their doctor.

The original drug Tepotinib is a new type of drug that has not yet been marketed in China, so it has not been included in the medical insurance. Domestic patients cannot yet purchase this drug in pharmacies or hospitals. The price of Tepotinib's original drug specification 225mg*30 tablets per box is around RMB 80,000 per box (the price may fluctuate due to exchange rate effects). It has been on the market for a short time and is expensive. There are also generic Tepotinib drugs produced in other countries. The price of a box of 225mg*60 tablets produced by a Lao pharmaceutical factory is around RMB 8,600 (the price may fluctuate due to the exchange rate). The ingredients of generic drugs produced abroad are basically the same as those of the original drug. For specific prices and drug details, please consult Yaode’s medical consultant.