What is the half-life of tepotinib?

The half-life of tepotinib (tepotinib) is approximately 32 hours. Half-life is the time it takes for a drug's concentration in the body to decrease by half. For tepotinib, the concentration of tepotinib in the body will decrease to half of the initial dose after approximately 32 hours. Tepotinib is a tyrosine kinase inhibitor (TKI) that mainly acts on the activity of the MET receptor to treat adult patients with metastatic non-small cell lung cancer with mesenchymal-epithelial transition (MET) exon 14 skipping changes.

Tepotinib exposure (AUC0-12h and Cmax) increased dose-proportionally over the dose range of 27 mg (0.06 times the recommended daily dose) to 450 mg. At the recommended dose, the geometric mean steady-state Cmax was 1291 ng/mL (48.1%) and the AUC0-24 hours was 27,438 ng/hour (51.7%). The oral clearance of tepotinib does not change over time. Following multiple daily doses of tepotinib, the median cumulative Cmax and AUC from 0 to 24 hours were 2.5-fold and 3.3-fold, respectively.

The original drug Tepotinib is a new type of drug that has not yet been marketed in China, so it has not been included in the medical insurance. Domestic patients cannot yet purchase this drug in pharmacies or hospitals. The price of Tepotinib's original drug specification 225mg*30 tablets per box is around RMB 80,000 per box (the price may fluctuate due to exchange rate effects). It has been on the market for a short time and is expensive. There are also generic Tepotinib drugs produced in other countries. The price of a box of 225mg*60 tablets produced by a Lao pharmaceutical factory is around RMB 8,600 (the price may fluctuate due to the exchange rate). The ingredients of generic drugs produced abroad are basically the same as those of the original drug. For specific prices and drug details, please consult Yaode’s medical consultant.