What type of drug does Bedaquiline belong to?

Bedaquiline tablets (Bedaquiline) is an anti-tuberculosis drug that is an ATP synthase inhibitor. The drug classification, mechanism of action and clinical application of bedaquiline tablets will be introduced in detail below.

Bedaquiline tablets are a member of the treatment drugs for multidrug-resistant tuberculosis (MDR-TB). Multidrug-resistant tuberculosis refers to tuberculosis caused by tuberculosis bacteria that are resistant to conventional drugs used to treat tuberculosis infections, such as isoniazid and rifampicin. Bedaquiline tablets are a new generation of anti-tuberculosis drugs that are widely used in the treatment of multidrug-resistant tuberculosis.

The main mechanism of action of Bedaquiline Tablets is by inhibiting ATP synthase during the cell wall synthesis of Mycobacterium tuberculosis. ATPSynthase is a key enzyme involved in the energy metabolism of Mycobacterium tuberculosis. Bedaquiline tablets can bind to the ATP subunit c and interfere with the function of the enzyme, thereby inhibiting the energy metabolism of bacteria and preventing bacteria from growing and replicating. This specific mechanism of action enables bedaquiline tablets to have a bactericidal effect on multidrug-resistant tuberculosis bacteria.

Bedaquiline tablets are often used in combination with other anti-tuberculosis drugs as part of a comprehensive treatment regimen for multidrug-resistant tuberculosis. It is widely used to treat patients with multidrug-resistant tuberculosis to improve the effectiveness and success rate of treatment. Treatment regimens with bedaquiline tablets usually need to be individualized based on the patient's individual situation and the results of resistance testing.

The application of bedaquiline tablets has the following characteristics:

1.Improve the success rate of treatment: The addition of bedaquiline tablets can significantly improve the success rate of treatment of multidrug-resistant tuberculosis. Multidrug-resistant tuberculosis usually has a low treatment success rate, but the application of bedaquiline tablets can improve this situation.

2.Reducing relapse: The use of bedaquiline tablets can reduce the relapse of multidrug-resistant tuberculosis after cure. It kills tuberculosis bacteria and reduces the risk of recurrence.

3.Shorten treatment time: The addition of bedaquiline tablets can shorten the treatment time of multidrug-resistant tuberculosis. Traditional treatment of multidrug-resistant tuberculosis usually requires long-term drug treatment, and the use of bedaquiline tablets can accelerate the achievement of efficacy.

4.Reducing transmission: Multidrug-resistant tuberculosis is a highly contagious disease that spreads easily within communities and health care facilities. The use of bedaquiline tablets helps reduce the spread of tuberculosis bacteria, thereby reducing public health risks.

In summary, bedaquiline tablets are an anti-tuberculosis drug that is an ATP synthase inhibitor and is mainly used to treat multidrug-resistant tuberculosis. It inhibits ATP synthase in the cell wall synthesis process of Mycobacterium tuberculosis, interfering with the energy metabolism of bacteria, thereby producing a bactericidal effect on Mycobacterium tuberculosis. Bedaquiline tablets, as part of a comprehensive treatment regimen, can improve the success rate of treatment, reduce recurrence, shorten treatment time and reduce the risk of transmission. When using bedaquiline tablets, you need to follow your doctor's guidance and make individualized treatment adjustments based on individual circumstances and the results of resistance tests.

Bedaquiline tablets have been launched in China and have been included in Class B medical insurance. Patients can buy it domestically, but the price is very high. The price of 100mg*24tablets is around 15,000 yuan. For specific prices, please consult the local hospital pharmacy. There are only original drugs abroad, and the more cost-effective ones are Russian original drugs. The price of 100mg*188 tablets is also about 15,000 yuan. The specifications are about 8 times that of domestic ones. Relatively speaking, the price is still very cheap compared to domestic ones. And the ingredients of domestic and foreign original drugs are consistent.